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Many people with allergies take antihistamines for relief. Studies show that several over-the-counter allergy medications are safe to use during pregnancy, including

  • chlorpheniramine

  • dexchlorpheniramine

  • hydroxyzine

Newer antihistamines, such as cetirizine and loratadine, also may be safe. There also is a corticosteroid nasal spray that is safe to use during pregnancy. But one of the most common decongestants, pseudoephedrine, has been linked to a small risk of abdominal wall birth defects. Do not use pseudoephedrine during the first 3 months of pregnancy.

Check with your ob-gyn before taking any over-the-counter allergy medication.

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Published: February 2021

Last reviewed: February 2021

Copyright 2021 by the American College of Obstetricians and Gynecologists. All rights reserved. Read copyright and permissions information.

This information is designed as an educational aid for the public. It offers current information and opinions related to women's health. It is not intended as a statement of the standard of care. It does not explain all of the proper treatments or methods of care. It is not a substitute for the advice of a physician. Read ACOG’s complete disclaimer.