ABSTRACT: Deep vein thrombosis (DVT) and pulmonary embolism (PE) are collectively referred to as “venous thromboembolic events” (VTE). Despite advances in prophylaxis, diagnosis, and treatment, VTE remains a leading cause of cost, disability, and death in postoperative and hospitalized patients 1 2. Beyond the acute sequelae of leg pain, edema, and respiratory distress, VTE may result in chronic conditions, including postthrombotic syndrome 3, venous insufficiency, and pulmonary hypertension. This Practice Bulletin has been revised to reflect updated literature on the prevention of VTE in patients undergoing gynecologic surgery and the current surgical thromboprophylaxis guidelines from the American College of Chest Physicians 4. Discussion of gynecologic surgery and chronic antithrombotic therapy is beyond the scope of this document.