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Although most babies are born healthy, parents-to-be often worry about the possibility that their baby will be born with a medical condition or physical disability. A birth defect is a physical problem or intellectual disability that is present at birth, although some birth defects may not be noticed until the child is older. About 3 in 100 babies in the United States are born with a major birth defect


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PFSI010 ››› Weeks 1–4 Weeks 5–8 Weeks 9–12 Weeks 13–16 Weeks 17–20 Weeks 21–24 • Timing: 10–13 weeks • Blood test plus NT ultrasound exam • Screens for Down • syndrome and trisomy 18 First-trimester screening Second-trimester screening (“quad screen”) • Timing: 15–22 weeks • Blood test • Screens for Down syndrome, trisomy 13, trisomy 18, and NTDs Standard ultrasound exam • Timing: 18–22 weeks • Screens for some physical defects Integrated screening and sequential screening • Timing: 10–22 weeks • Combines first-trimester and second-trimester screening test results in vari...


American College of Obstetricians and Gynecologists
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