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| This document reflects emerging clinical and scientific advances as of the date issued and is subject to change. The information should not be construed as dictating an exclusive course of treatment or procedure to be followed.
Copyright © January 2003
by the American College of Obstetricians and Gynecologists. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without prior written permission from the publisher.
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Immunization during pregnancy. ACOG Committee Opinion No. 282. American College of Obstetricians and Gynecologists. Obstet Gynecol 2003; 101:207–12.
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ACOG publications are protected by copyright and all rights are reserved. ACOG publications may not be reproduced in any form or by any means without written permission from the copyright owner. This includes the posting of electronic files on the Internet, transferring electronic files to other persons, distributing printed output, and photocopying. Requests for authorization to make photocopies should be directed to: Copyright Clearing Center, 222 Rosewood Drive, Danvers, MA 01923 (978) 750-8400
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Committee
Opinion 
Immunization During Pregnancy
ABSTRACT: Preconceptional immunization of pregnant women to prevent disease in the offspring, when practical, is preferred to vaccination of pregnant women. The benefits of immunization to the pregnant woman and her neonate usually outweigh the theoretic risks of adverse effects. Current information on the safety of vaccines given during pregnancy is subject to change and can be verified from the Centers for Disease Control and Prevention web site at www.cdc.gov/nip.
The benefits of immunization to the pregnant woman and her neonate usually outweigh the theoretic risks of adverse effects. The theoretic risks of the vaccination of pregnant women with killed virus vaccines have not been identified.
Current recommendations for immunization of pregnant women are presented in Table 1. Although new information continues to confirm the safety of vaccines intentionally or inadvertently given during pregnancy, current information is subject to change because the effects of many diseases and vaccines on the pregnant woman or the fetus may be rare and infrequently reported. (For further information and updates refer to www.cdc.gov/nip.)
In the decision of whether to immunize a pregnant woman with other vaccines not listed in Table 1, the risk for exposure to disease and its deleterious effects on the pregnant woman and the fetus must be balanced against the efficacy of the vaccine and any beneficial effects resulting from it. Preconceptional immunization of women to prevent disease in the offspring, when practical, is preferred to vaccination of pregnant women with certain vaccines. Vaccination of women during the postpartum period, especially for rubella and varicella, should be encouraged. Women susceptible to rubella should be vaccinated with measles–mumps–rubella on postpartum discharge from the hospital.
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