Answers to the CME Quiz for "Medications in Pregnancy and Lactation: Part 1. Teratology" by Catalin S. Buhimschi, MD, and Carl P. Weiner, MD, MBA (Obstet Gynecol 2009;113:166-88)

1. The use of genomics and proteomics to affect clinical diagnosis, vaccine development, drug discovery, and unique therapies is referred to as:

B. Theranostics

2. The majority of the current literature regarding drug teratogenicity during pregnancy consists of:

C. Case-control studies

3. Which of the following has a role in placental diffusion of drugs from the mother to the fetus?

E. Receptor site affinity

4. If an effect is seen because of exposure to a teratogenic substance during the preimplantation period, it is generally:

E. Embryonic loss

5. Gastroschisis is associated with nonsteroidal antiinflammatory drugs (NSAIDs) during what period of gestation?

B. Early gestation

6. Recent studies suggest that angiotensin-converting enzyme (ACE) inhibitors are associated with malformations if used during what period of gestation?

E. All stages of gestation

7. The teratogenicity of a new drug is generally detected at what stage of development?

E. After marketing (Phase III)

8. If adequate, well-controlled or observational studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities, the drug would be placed in Food and Drug Administration (FDA) category:

E. X

9. Approximately what percentage of congenital anomalies is associated with a particular drug exposure?

A. 10%

10. Which of the following resources for drug effects in pregnancy was specifically developed to provide summary information to health care providers on the effects of chemical and physical agents on fertility, pregnancy, and lactation?

D. Reprotox

ACCME Accreditation: The American College of Obstetricians and Gynecologists (ACOG) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. (Continuing medical education credit for " Medications in Pregnancy and Lactation: Part 1. Teratology" will be available through January 2012.)

AMA PRA Category 1 Credit^TM and ACOG Cognate Credit: The American College of Obstetricians and Gynecologists (ACOG) designates this educational activity for a maximum of 2 AMA PRA Category 1 Credits^TM or up to a maximum of 2 Category 1 ACOG cognate credits. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Disclosure Statement: Current guidelines state that continuing medical education (CME) providers must ensure that CME activities are free from the control of any commercial interest. All authors, reviewers, and contributors have disclosed to ACOG all relevant financial relationships with any commercial interests. The authors, reviewers, and contributors declare that neither they nor any business associate nor any member of their immediate families has financial interest or other relationships with any manufacturer of products or any providers of services discussed in this program. Any conflicts have been resolved through group and outside review of all content.

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