Answers to the CME Quiz for "Management of Rhesus Alloimmunization in Pregnancy” by Kenneth J. Moise Jr, MD (Obstet Gynecol 2008;112:164-76)

1. It is estimated that approximately what percent of patients in the third trimester will have 0.01 mL or more of fetal cells detectable in maternal circulation?

D. 45%

2. For pregnant RhD-negative women who show no evidence of alloimmunization, rhesus immune globulin should be given:

D. At 28 weeks of gestation

3. It is estimated that with appropriate use of rhesus immune globulin prophylaxis for RhD-negative pregnant women, the incidence of alloimmunization is reduced to approximately:

A. 0.1%

4. When a 300-microgram dose of rhesus immune globulin is given following delivery, it is sufficient to protect against fetomaternal hemorrhage of what volume of fetal whole blood?

D. 30 mL

5. Excessive fetomaternal hemorrhage is thought to occur in:

C. 1 in 1,000 deliveries

6. Approximately what percentage of RhD-positive individuals are heterozygous at the RHD locus?

C. 50%

7. Hydrops fetalis generally occurs when fetal hemoglobin drops by approximately:

C. 7 g/dL

8. The most appropriate vessel to use for Doppler assessment of fetal anemia is the:

A. Middle cerebral artery

9. When intrauterine fetal transfusions are undertaken, the blood usually undergoes irradiation prior to use. The purpose of this irradiation is to:

D. Reduce graft-versus-host reactions

ACCME Accreditation: The American College of Obstetricians and Gynecologists (ACOG) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. (Continuing medical education credit for "Management of Rhesus Alloimmunization in Pregnancy” will be available through July 2011.)

AMA PRA Category 1 Credit^TM and ACOG Cognate Credit: The American College of Obstetricians and Gynecologists (ACOG) designates this educational activity for a maximum of 2 AMA PRA Category 1 Credits^TM or up to a maximum of 2 Category 1 ACOG cognate credits. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Disclosure Statement: Current guidelines state that continuing medical education (CME) providers must ensure that CME activities are free from the control of any commercial interest. All authors, reviewers, and contributors have disclosed to ACOG all relevant financial relationships with any commercial interests. The authors have made the following disclosures: Dr. Moise is a consultant and received research funding from Sequenom, Inc. (San Diego, CA). Any conflicts have been resolved through group and outside review of all content.

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