Carrier Screening for Fragile X Syndrome

Number 469

(Replaces No. 338, June 2006)

ABSTRACT: Fragile X syndrome is the most common inherited form of mental retardation. The syndrome occurs in approximately 1 in 3,600 males and 1 in 4,000–6,000 females. Approximately 1 in 250 female...

Influenza Vaccination During Pregnancy

Number 468

(Replaces No. 305, November 2004)

ABSTRACT: Preventing influenza during pregnancy is an essential element of prenatal care, and the most effective strategy for preventing influenza is annual immunization. The Centers for Disease Cont...

Moderate Caffeine Consumption During Pregnancy

Number 462

ABSTRACT: Moderate caffeine consumption (less than 200 mg per day) does not appear to be a major contributing factor in miscarriage or preterm birth. The relationship of caffeine to growth restrictio...

Screening for Depression During and After Pregnancy

Number 453

(Reaffirmed 2012)

Abstract: Depression is very common during pregnancy and the postpartum period. At this time, there is insufficient evidence to support a firm recommendation for universal antepartum or postpartum sc...

Maternal Phenylketonuria

Number 449

(Replaces No. 230, January 2000)

ABSTRACT: Phenylketonuria (PKU) is an autosomal recessive disorder of phenylalanine (Phe) metabolism characterized by a deficiency of the hepatic enzyme, phenylalanine hydroxylase, an enzyme responsi...

Array Comparative Genomic Hybridization in Prenatal Diagnosis

Number 446

ABSTRACT: The widespread use of array comparative genomic hybridization (CGH) for the diagnosis of genomic rearrangements in children with idiopathic mental retardation, developmental delay, and mult...

Air Travel During Pregnancy

Number 443

(Replaces No. 264, December 2001)

ABSTRACT: In the absence of obstetric or medical complications, pregnant women can observe the same precautions for air travel as the general population and can fly safely. Pregnant women should be i...

Preconception and Prenatal Carrier Screening for Genetic Diseases in Individuals of Eastern European Jewish Descent

Number 442

(Replaces No. 298, August 2004)

ABSTRACT: Certain autosomal recessive disease conditions are more prevalent in individuals of Eastern European Jewish (Ashkenazi) descent. Previously, the American College of Obstetricians and Gyneco...

Spinal Muscular Atrophy

Number 432

ABSTRACT: Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease that results from degeneration of spinal cord motor neurons leading to atrophy of skeletal muscle and overa...

Prenatal and Perinatal Human Immunodeficiency Virus Testing - Expanded Recommendations

Number 418

(Reaffirmed 2011, Replaces No. 304, November 2004)

ABSTRACT: Early identification and treatment of all pregnant women with human immunodeficiency virus (HIV) is the best way to prevent neonatal disease and improve the woman's health. Human immunodefi...

Surrogate Motherhood

Number 397

ABSTRACT: Ethical responsibilities are described for obstetrician–gynecologists who choose to participate in surrogacy arrangements by 1) advising couples who are considering surrogacy, 2) counseling...

Maternal Decision Making Ethics and the Law

Number 321

ABSTRACT: Recent legal actions and policies aimed at protecting the fetus as an entity separate from the woman have challenged the rights of pregnant women to make decisions about medical interventio...

Screening for Tay - Sachs Disease

Number 318

(Reaffirmed 2010, Replaces No. 162, November 1995)

ABSTRACT: Tay–Sachs disease (TSD) is a severe progressive neurologic disease that causes death in early childhood. Carrier screening should be offered before pregnancy to individuals and couples at h...

Guidelines for Diagnostic Imaging During Pregnancy

Number 299

(Reaffirmed 2009, Replaces No. 158, September 1995)

ABSTRACT: Undergoing a single diagnostic X-ray procedure does not result in radiation exposure adequate to threaten the well-being of the developing preembryo, embryo, or fetus and is not an indicati...

Nonmedical use of Obstetric Ultrasonography

Number 297

(Reaffirmed 2012)

ABSTRACT: The American College of Obstetricians and Gynecologists (ACOG) has endorsed the "Prudent Use" statement from the American Institute of Ultrasound in Medicine (AIUM) discouraging the use of ...

Management of Asymptomatic Pregnant or Lactating Women Exposed to Anthrax

Number 268

ABSTRACT: Anthrax infections are diagnosed by isolating Bacillus anthracis from body fluids or by measuring specific antibodies in the blood of persons suspected to have the disease. It is recommende...