Featured Practice Bulletin

Lynch Syndrome

Lynch syndrome, previously known as hereditary nonpolyposis colorectal cancer, is an autosomal dominant inherited cancer susceptibility syndrome caused by defects in the mismatch repair system. This system depends on a family of genes that are conserved across most living organisms and is responsible for repairing single-base mismatches that occur during DNA replication. In addition to colorectal cancer, hallmark diseases of Lynch syndrome include endometrial and ovarian cancer. Other tumors within the spectrum of Lynch syndrome include gastric cancer, small bowel cancer, hepatobiliary cancer, renal pelvis and ureter cancer, as well as some types of breast cancer, certain brain tumors, and sebaceous skin tumors. By identifying individuals at risk of Lynch syndrome through assessment of personal and family medical histories and genetic counseling and testing, when indicated, physicians are able to offer screening and prevention strategies to reduce morbidity and mortality from this syndrome.


Each of the 5 units of PROLOG addresses a major area in obstetrics and gynecology and consists of two parts—an assessment book and a critique book. Put your knowledge to the test and earn CME credits.

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ACOG eModules

PROLOG eModules

ACOG eModules are a brand new concept merging the best attributes of PROLOG and PRECIS into an online modular format.


Clinical Updates

Clinical Updates

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