FDA Releases Safety Alert on Fluconazole (Diflucan) Use in Pregnancy

The U.S. Food and Drug Administration (FDA) released a safety alert on fluconazole (Diflucan) use in pregnancy. The FDA is evaluating the results of a recent study that concluded there is a possible risk of miscarriage with the use of oral fluconazole for yeast infections. Until FDA’s review is complete and more is understood about this study and other available data, the FDA advises cautious prescribing of oral fluconazole in pregnancy.


The American College of Obstetricians and Gynecologists notes in its Practice Bulletin #72: Vaginitis that treatment of vulvovaginal candidiasis in pregnancy should consist of one of the topical imidazole therapies. The Centers for Disease Control and Prevention recommends only using topical antifungal products to treat pregnant women with vulvovaginal yeast infections, including for longer periods than usual if these infections persist or recur.

American Congress of Obstetricians and Gynecologists
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